Help build the Manchester Stroke Brain Collection

Making tissue samples available for research into stroke treatments.

Stroke remains a major area of unmet need, being the second leading cause of death and the primary cause of neurological disability worldwide.

Mortality rates for certain types of stroke remain as high as ~40% within one month, a statistic that has shown little improvement over the past several decades. Despite extensive research, available treatments for stroke remain extremely limited.

Consequently, there is an urgent need for the development of novel and effective therapies for all types of stroke.

Why funding is needed

This project seeks funding to support the establishment of a Manchester Stroke Brain Collection.

This will cover all aspects of the process, including ethical approval, consent procedures, tissue collection, processing, banking, and linkage to clinical data.

How tissue samples could help stroke research

Translational research is essential to the development of new treatments and requires evidence from a variety of studies and experimental models.

Ideally, this research should involve the evaluation of human post-mortem tissue to confirm the translational relevance of findings and identify potential therapeutic targets.

While the use of post-mortem brain tissue is standard in neurodegenerative disease research, such as Alzheimer’s disease, it is far less common in stroke research due to the limited availability of high-quality, clinically annotated tissue.

For instance, although the Manchester Brain Bank (MBB) provides access to hundreds of well-characterised tissue samples for Alzheimer’s disease and other dementias, it has a relatively small number of stroke cases.

Contact us

If you have any questions, please email us at GJBRC@manchester.ac.uk.