Finding new treatments for NF2-schwannomatosis

Exploring new ways to tackle non-cancerous tumours on the nerves.

NF2-schwannomatosis is a rare condition where non-cancerous tumours, known as schwannomas, grow on nerves.

These tumours often appear around the brain, spine, or other parts of the body and can cause symptoms such as hearing loss, balance issues, muscle weakness, and chronic pain, depending on their location.

The condition is caused by changes in the NF2 gene, which normally helps regulate cell growth. Diagnosing NF2-schwannomatosis usually involves scans, genetic testing, and thorough medical assessments.

Why funding is needed

We need £50,000 to cover the cost of research staff and laboratory materials so we can perform immunological studies in clinical samples and pre-clinical models to assess how targeting identified pathways reduces the growth rate and complications of NF2-schwannomatosis-related tumours.

Any contribution, big or small, will make a significant difference and help us reach our goal.

How researchers are investigating new approaches

New treatments for NF2 schwannomatosis are urgently needed because current options, like surgery and radiation, focus on managing symptoms rather than addressing the underlying cause.

We are utilising cutting-edge approaches and novel models to study the immune response to different tumours in individuals with NF2-schwannomatosis. This is to allow us to identify essential new treatments for patients with the disease.

Contact us

If you have any questions, please email us at GJBRC@manchester.ac.uk.